2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N9257
    8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside 112747-99-6 98%
    8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside (Compound 7) is a compound derived from roots and rhizomes. 8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside could prevent neurotoxicity in PC12 cells.
    8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside
  • HY-N9283
    1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran 146905-24-0 98%
    1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran, isolated from the edible mushroom Sarcodon leucopus, has antioxidant effects in the DPPH scavenging assay with the IC50 of 28 μM, inhibits malondialdehyde (MDA) with the IC50 of 71 μM, and inhibits α-glucosidase with the IC50 of 6.22 μM.
    1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran
  • HY-N9335
    Myrciacetin 203734-35-4 98%
    Myrciacetin is a flavonoid from Rhododendron dauricum. Myrciacetin is against rat lens aldose reductase with an IC50 of 13 μM.
    Myrciacetin
  • HY-N9338
    Guattegaumerine 21446-35-5 98%
    Guattegaumerine is a bisbenzylisoquinoline alkaloid?with antimitotic, cytotoxic and neuroprotective activities.
    Guattegaumerine
  • HY-N9373
    Bacoside A2 58798-95-1 98%
    Bacoside A2 is a triterpenoid saponin.
    Bacoside A2
  • HY-N9504
    Polyschistine A 96562-88-8 98%
    Polyschistine A is a norditerpene alkaloid with potential analgesic properties.
    Polyschistine A
  • HY-N9513
    Echimidine N-oxide 41093-89-4 98%
    Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC50=0.347 mM).
    Echimidine N-oxide
  • HY-N9515
    Diallyl tetrasulfide 2444-49-7 98%
    Diallyl tetrasulfide is an orally active diallyl tetrasulfide. Diallyl tetrasulfide ameliorates cadmium-induced changes in acetylcholinesterase and adenosine triphosphatase activities as well as oxidative stress injury in the brain of rats. Diallyl tetrasulfide inhibits lipid peroxidation in rat liver microsomes. Diallyl tetrasulfide ameliorates cadmium-induced oxidative liver injury in rats. Diallyl tetrasulfide protects cells against cadmium-induced loss of cell viability, reduces apoptosis rate and ROS production. Diallyl tetrasulfide is applicable to research related to cadmium-induced neurotoxicity and cadmium-induced oxidative liver injury.
    Diallyl tetrasulfide
  • HY-N9587
    Tricin 7-O-β-D-glucopyranoside 32769-01-0 98%
    Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1.
    Tricin 7-O-β-D-glucopyranoside
  • HY-N9615
    Azadiradione 26241-51-0 98%
    Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a HSF1 activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities.
    Azadiradione
  • HY-N9628
    Polygalatenoside A 946839-55-0 98%
    Polygalatenoside A is a noradrenaline reuptake inhibitor with an IC50 of 30.0 μM against human noradrenaline transporter. Polygalatenoside A can be used in the research of mental disorders.
    Polygalatenoside A
  • HY-N9736
    6,4'-Dihydroxy-7-methoxyflavanone 189689-32-5 98%
    6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis.
    6,4'-Dihydroxy-7-methoxyflavanone
  • HY-N9737
    (−)-Acutumine 17088-50-5 98%
    (−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model.
    (−)-Acutumine
  • HY-N9846
    Luteolin 5,3'-dimethyl ether 62346-14-9 98%
    Luteolin 5,3'-dimethyl ether is a flavonoid compound that exhibits strong binding to enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-Glycosidase. Luteolin 5,3'-dimethyl ether can be naturally extracted from the dried roots of Alhagi maurorum (camel thorn). The methanol extract of this plant has significant free radical scavenging ability and enzyme inhibitory potential. Luteolin 5,3'-dimethyl ether can be used in research related to neurodegenerative diseases, diabetes, and skin pigmentation-related diseases.
    Luteolin 5,3'-dimethyl ether
  • HY-N9878
    Pistaciamide 1029004-83-8 98%
    Pistaciamide is an N-phenyl-pyrrolidone derivative, and its related pyrrolidone derivatives are commonly used in the treatment of neurological disorders, making it relevant for research of neurological dysfunction. Pistaciamide can be naturally extracted from the 90% ethanol extract of fresh shoots and inflorescences of Pistacia chinensis Bunge. (a plant of the Anacardiaceae family).
    Pistaciamide
  • HY-N9949
    Sparteine 24915-04-6 98%
    Sparteine (Lupinidine) is an alkaloid compound derived from leguminous plants and can act as a ganglionic blocker. Sparteine competitively inhibits the activity of the neuronal nicotinic acetylcholine receptor (nACh receptor).
    Sparteine
  • HY-NP208
    Myelin Basic Protein (Porcine)
    Myelin Basic Protein (Porcine), the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. Myelin Basic Protein (Porcine) mediates interactions with actin and tubulin and effect of post-translational modifications.
    Myelin Basic Protein (Porcine)
  • HY-P0041
    F992 162277-99-8 98%
    F992 is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.
    F992
  • HY-P0066
    Contulakin G 229180-41-0 98%
    Contulakin G is an O-glycosylated invertebrate neurotensin. Contulakin-G is a weaker agonist for the neurotensin receptor. Contulakin G is also a potent antinociceptive agent.
    Contulakin G
  • HY-P0133
    (Arg) 9 143413-47-2 98%
    (Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
    (Arg) 9
Cat. No. Product Name / Synonyms Application Reactivity